The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease
S. L. Castro, E. M. Rocha, C. R. Bodle, K. E. Johnson, J. T. Greenamyre, B. R. De Miranda
This study shows that trichloroethylene exposure activates LRRK2 kinase and causes dopaminergic neurodegeneration in rats, linking environmental toxins to Parkinson's disease risk.
bioRxiv · Nov 2, 2020Pharmacology & Toxicology