Evaluation of Mosaicism and Off Target Mutations in CRISPR-Mediated Genome Edited Bovine Embryos
S. L. Henning, J. R. Owen, J. C. Lin, A. E. Young, P. J. ROSS, A. L. Van Eenennaam, J. D. Murray
This study compares Cas9 mRNA and protein in bovine embryo editing, finding higher mutation efficiency and lower mosaicism with Cas9 protein, but no off-target mutations.
bioRxiv · Jun 4, 2020Bioengineering