Author

J. R. Owen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:chicken / avian· 1 Assay:clinical cohort / trial· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. E. Young· 2 shared A. L. Van Eenennaam· 2 shared J. C. Lin· 2 shared J. D. Murray· 2 shared P. J. Ross· 2 shared A. M. Franchini· 1 shared B. R. McNabb· 1 shared E. M. Schwarz· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

A. E. Young

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Biphasic effects of IL-27 during Staphylococcus aureus implant-associated osteomyelitis in mice

Y. Morita, A. M. Franchini, J. R. Owen, J. C. Martinez, J. L. Daiss, K. L. de Mesy Bentley, S. L. Kates, E. M. Schwarz, G. Muthukrishnan

This study identifies IL-27 as a biphasic cytokine with proinflammatory and anti-inflammatory roles during S. aureus osteomyelitis, suggesting it as a therapeutic target.

bioRxiv · May 20, 2021 · PreprintImmunology

Harnessing endogenous repair mechanisms for targeted gene knock-in of bovine embryos

J. R. Owen, S. L. Hennig, B. R. McNabb, J. C. Lin, A. E. Young, J. D. Murray, P. J. Ross, A. L. Van Eenennaam

This study compares gene knock-in efficiency in bovine zygotes using homology-directed repair (HDR) and homology-mediated end joining (HMEJ) templates, finding HMEJ achieves higher knock-in rates and lower mosaicism.

bioRxiv · Jun 9, 2020Bioengineering

Evaluation of Mosaicism and Off Target Mutations in CRISPR-Mediated Genome Edited Bovine Embryos

S. L. Henning, J. R. Owen, J. C. Lin, A. E. Young, P. J. ROSS, A. L. Van Eenennaam, J. D. Murray

This study compares Cas9 mRNA and protein in bovine embryo editing, finding higher mutation efficiency and lower mosaicism with Cas9 protein, but no off-target mutations.

bioRxiv · Jun 4, 2020Bioengineering