Author

J. C. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:chicken / avian· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. E. Young· 2 shared A. L. Van Eenennaam· 2 shared J. D. Murray· 2 shared J. R. Owen· 2 shared P. J. Ross· 2 shared A. J. Murphy· 1 shared A. Rafique· 1 shared B. R. McNabb· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

A. E. Young

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM

K. Saotome, D. Dudgeon, K. Colotti, M. J. Moore, J. Jones, Y. Zhou, A. Rafique, G. D. Yancopoulos, A. J. Murphy, J. C. Lin, W. C. Olson, M. C. Franklin

The paper reports cryoEM structures of TCR-CD3 complexes and pMHC ligands, revealing structural insights into TCR recognition of cancer antigens.

bioRxiv · Aug 18, 2022Biochemistry

Harnessing endogenous repair mechanisms for targeted gene knock-in of bovine embryos

J. R. Owen, S. L. Hennig, B. R. McNabb, J. C. Lin, A. E. Young, J. D. Murray, P. J. Ross, A. L. Van Eenennaam

This study compares gene knock-in efficiency in bovine zygotes using homology-directed repair (HDR) and homology-mediated end joining (HMEJ) templates, finding HMEJ achieves higher knock-in rates and lower mosaicism.

bioRxiv · Jun 9, 2020Bioengineering

Evaluation of Mosaicism and Off Target Mutations in CRISPR-Mediated Genome Edited Bovine Embryos

S. L. Henning, J. R. Owen, J. C. Lin, A. E. Young, P. J. ROSS, A. L. Van Eenennaam, J. D. Murray

This study compares Cas9 mRNA and protein in bovine embryo editing, finding higher mutation efficiency and lower mosaicism with Cas9 protein, but no off-target mutations.

bioRxiv · Jun 4, 2020Bioengineering