Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
M. Day, S. L. Parry-Morris, J. Houghton-Gisby, A. W. Oliver, L. H. Pearl
This study determines the crystal structure of CHK1 kinase domain bound to a CLASPIN motif, revealing its role as a scaffold for CHK1 activation by ATR.
bioRxiv · Oct 2, 2020Biochemistry