Author

L. H. Pearl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Day· 3 shared A. Oliver· 2 shared A. W. Oliver· 2 shared C. E. L. Fisher· 1 shared C. Prodromou· 1 shared D. Bjorklund· 1 shared E. L. Hesketh· 1 shared F. M. G. Pearl· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiochemistry

M. Day

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Author profile →

5 papers

Recent·Most cited

Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction

M. Day, A. Oliver, L. H. Pearl

The paper determines the structure of the human RAD17-RFC clamp loader complex bound to 9-1-1 and a dsDNA-ssDNA junction, explaining specificity and orientation mechanisms.

bioRxiv · Mar 11, 2022Biochemistry

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

X. Chen, Y. Ali, C. E. L. Fisher, R. Arribas-Bosacoma, M. B. Rajasekaran, G. Williams, S. Walker, J. R. Booth, J. J. R. Hudson, S. M. Roe, L. H. Pearl, S. E. Ward, F. M. G. Pearl, A. W. Oliver

The paper identifies an allosteric inhibitor of BLM's ATPase-coupled DNA helicase activity and characterizes its mechanism through crystallographic analysis.

bioRxiv · Nov 30, 2020Biochemistry

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

M. Pal, H. Munoz-Hernandez, D. Bjorklund, L. Zhou, G. Degliesposti, J. M. Skehel, E. L. Hesketh, R. F. Thompson, L. H. Pearl, O. Llorca, C. Prodromou

The paper determines the cryo-EM structure of the human R2TP-TTT complex and shows how TTT recruits TOR to R2TP while regulating its chaperone activity.

bioRxiv · Nov 9, 2020Biochemistry

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein

M. Day, S. L. Parry-Morris, J. Houghton-Gisby, A. W. Oliver, L. H. Pearl

This study determines the crystal structure of CHK1 kinase domain bound to a CLASPIN motif, revealing its role as a scaffold for CHK1 activation by ATR.

bioRxiv · Oct 2, 2020Biochemistry

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

L. H. Pearl, N. Bigot, M. Day, R. A. Baldock, F. Z. Watts, A. Oliver

This study identifies a phosphorylation-dependent interaction between 53BP1 and TOPBP1 that is critical for the G1 DNA damage checkpoint by recruiting ATR and CHK1 to damage foci.

bioRxiv · Jan 2, 2019Cell Biology