Molecular insight into the enzymatic macrocyclization of multiply backbone N-methylated peptides
E. Matabaro, H. Song, F. Gherlone, L. Sonderegger, A. Giltrap, S. Liver, A. Gossert, M. Künzler, J. H. Naismith
This study characterizes OphP, an enzyme that macrocyclizes multiply N-methylated peptides, revealing its unique substrate specificity and mechanism.
Chemical Science · Jan 1, 2025Peer-reviewedBiochemistry