H. Song

Apparent generalism in Pseudomonas aeruginosa is underpinned by Convergent, Cryptic Specialization

The paper shows that Pseudomonas aeruginosa's apparent generalism is due to convergent, cryptic specialization across environments, not strict generalism or lineage-specific specialization.

Molecular insight into the enzymatic macrocyclization of multiply backbone N-methylated peptides

This study characterizes OphP, an enzyme that macrocyclizes multiply N-methylated peptides, revealing its unique substrate specificity and mechanism.

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors

This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.

Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.

Genetic signatures in the highly virulent subtype B HIV-1 conferring immune escape to V1/V2 and V3 broadly neutralizing antibodies

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Dispersal and evolution of the invasive snail Pomacea canaliculata, an intermediate host of Angiostrongylus cantonensis: A field study around its initial introduction site in China

This study investigates the spatial distribution, phenotypic variation, and dispersal patterns of the invasive snail Pomacea canaliculata in China, revealing human-mediated evolution and potential complexities in parasite transmission.

Vitamin D attenuates diabetic myocardial injury via the Erbb4/ferroptosis axis

This study shows vitamin D reduces diabetic myocardial injury by inhibiting the Erbb4/ferroptosis pathway in both in vivo and in vitro models.

RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4

This study identifies RPL22 as a tumor suppressor in MSI-H cancers that regulates MDM4 splicing and reveals its role in oncogenic pathways.

A compact, ultrahigh-density headstage with high-fidelity hybrid integration for large-scale deep-brain opto-electrophysiology

This paper introduces a high-channel-count optogenetic system for deep-brain studies, achieving high spatial resolution in recording and stimulation with unprecedented channel density.

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype

The paper identifies an X4-tropic HIV-1 transmitted/founder virus in a person with wild-type CCR5, showing faster CD4 depletion and resistance to certain bNAbs.

Spatial profiling of neuro-immune interactions in gastroenteropancreatic NETs

This study uses spatial protein profiling to identify tissue-specific neuro-immune signatures in GEP-NETs, showing that duodenal gastrinomas express immune and pro-inflammatory factors that influence neuroendocrine traits.

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

Hypoxia Bi-directionally Regulates Gut Vascular Barrier through HIF-1α-dependent Mechanism in vitro

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

The paper tracks the coreceptor switch of HIV-1 in early infection, finding that a single mutation can drive X4 variants and co-evolution of antigenicity and tropism.

A new species of Nanhsiungchelys (Testudines: Cryptodira: Nanhsiungchelyidae) from the Upper Cretaceous of Nanxiong Basin, China, and the role of anterolateral processes on the carapace in drag reduction

The paper describes a new turtle species and investigates the function of carapace anterolateral processes using computational fluid dynamics.

Profile of the somatic mutational landscape in breast tumors from Hispanic/Latina women

This study analyzes the somatic mutational landscape of breast tumors in Hispanic/Latina women using whole-exome and RNA-seq, identifying common mutations and novel mutation signatures.

Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation in early brain development

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment

This study identifies YAP1-driven collagen VI deposition in sarcoma as a mechanism suppressing CD8+ T cell function through ECM remodeling and autophagy inhibition.

Transcriptome and DNA methylome dynamics reveal differential characteristics of inflorescence development between two ecotypes in Panicum hallii

A comparative transcriptome and DNA methylome analysis of inflorescence between upland and lowland ecotypes reveals gene expression and DNA methylation variation underlying inflorescence divergence in Panicum hallii.

Use of sugarcane mosaic virus for virus-induced gene silencing in maize

This study uses sugarcane mosaic virus to induce gene silencing in maize, showing it can effectively silence endogenous genes and assess the role of JA-Ile metabolism in plant defense.

The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression

This study identifies that the co-deletion of CIC and ERF leads to ETV1 activation, driving prostate cancer progression without fusion events.

Emergence of glycogen synthase kinase-3 interaction domain enhances phosphorylation of SARS-CoV-2 nucleocapsid protein

This study identifies a GSK-3 interacting domain in SARS-CoV-2 N protein that enhances its phosphorylation, with mutations in variants like Delta and Omicron increasing N abundance and phosphorylation.

Immune escape mutations selected by neutralizing antibodies in natural HIV-1 infection can alter coreceptor usage repertoire of the transmitted/founder virus

Single-cell analysis of hepatoblastoma identifies distinct tumor cell signatures that predict susceptibility to chemotherapy using patient-specific tumor spheroids

This study identifies five distinct tumor cell subtypes in hepatoblastoma using single-cell analysis and shows that patient-derived spheroids can predict chemotherapy response based on transcriptomic signatures.

Wild pigs mediate far-reaching agricultural impacts on tropical forest soil microbial communities

The paper shows that wild pigs, influenced by agriculture, alter soil microbial communities over 1 km into protected areas, affecting diversity and fungal abundance through leaf litter removal and plant changes.

Acoustic light-sheet microscopy

Acoustic light-sheet microscopy overcomes the trade-off between field-of-view and axial resolution in light-sheet microscopy by guiding light through acoustic pulses.

Membrane Fusion can be Driven by Sec18/NSF, Sec17/αSNAP, and trans-SNARE complex without HOPS

The paper shows that Sec17/αSNAP and Sec18/NSF can drive membrane fusion without HOPS by interacting with SNARE complexes and tethers.