Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets
A. P. Bye, W. Hoepel, J. L. Mitchell, S. Jegouic, S. Loureiro, T. Sage, S. de Taeye, M. van Gils, N. Kriek, N. Cooper, I. Jones, J. den Dunnen, J. M. Gibbins
The paper shows that aberrant glycosylation of anti-SARS-CoV-2 IgG enhances platelet activation and thrombosis via FcyRIIA, which can be inhibited by tyrosine kinase inhibitors and P2Y12 antagonists.
bioRxiv · Mar 26, 2021Immunology