A loss-of-function cysteine mutant in fibulin-3 (EFEMP1) forms aberrant extracellular disulfide-linked homodimers and alters extracellular matrix composition
D. R. Woodard, S. Daniel, E. Nakahara, A. Abbas, S. M. DiCesare, J. D. Hulleman
This study investigates how a cysteine mutation in fibulin-3 (C55R) disrupts its structure and function, leading to altered extracellular matrix composition and impaired ECM remodeling.
bioRxiv · Feb 25, 2022Biochemistry