BiochemistrybioRxiv
A loss-of-function cysteine mutant in fibulin-3 (EFEMP1) forms aberrant extracellular disulfide-linked homodimers and alters extracellular matrix composition
D. R. Woodard, S. Daniel, E. Nakahara…·J. D. Hulleman
This study investigates how a cysteine mutation in fibulin-3 (C55R) disrupts its structure and function, leading to altered extracellular matrix composition and impaired ECM remodeling.
DOI 10.1002/humu.24452