Inositol Phosphorlyceramide Synthase null Leishmania major (Δipcs-) are viable and virulent in animal infections where salvage of host sphingomyelin predominates
F. M. Kuhlmann, P. N. Key, S. M. Hickerson, J. Turk, F.-F. Hsu, S. M. Beverley
This study shows that Leishmania major lacking inositol phosphorlyceramide synthase (IPCS) remains viable and virulent in mice, suggesting SM salvage compensates for IPC loss.
bioRxiv · Jun 14, 2022Microbiology