High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis
D. M. Mason, C. R. Weber, C. Parola, S. M. Meng, V. Greiff, W. J. Kelton, S. T. Reddy
This paper develops a high-throughput method for antibody engineering in mammalian cells using CRISPR/Cas9-mediated homology-directed mutagenesis, demonstrating improved efficiency and applicability for variant discovery and optimization.
bioRxiv · Mar 19, 2018Bioengineering