Cancer BiologybioRxiv
Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH
M. R. Swiatnicki, J. P. Rennhack, D. Hollern…·E. R. Andrechek
This paper shows that PTPRH mutations in NSCLC lead to elevated EGFR phosphorylation, which can be targeted by existing EGFR inhibitors.
DOI 10.1371/journal.pgen.1010362