Author

E. R. Andrechek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

J. P. Rennhack· 3 shared D. Hollern· 2 shared M. R. Swiatnicki· 2 shared R. Kubiak· 2 shared A. McAuliff· 1 shared A. V. Perry· 1 shared B. C. Matson· 1 shared B. To· 1 shared

Activity by Year

2019-2024 · peak 2/yr

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10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

J. P. Rennhack

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5 papers

Recent·Most cited

Atypical Cell Cycle Regulation Promotes Mammary Stem Cell Expansion and Therapeutic Resistance

B.-A. Fifield, J. Vusich, E. Haberfellner, E. R. Andrechek, L. A. Porter

This study shows Spy1 promotes mammary stem cell expansion and therapy resistance by overriding cell cycle checkpoints, especially in combination with p53 loss, leading to more aggressive breast cancers.

bioRxiv · Mar 5, 2024 · PreprintCancer Biology

Insight into mammary gland development and tumor prevention in a newly developed metastatic mouse model of breast cancer

B. To, C. Broeker, J.-R. Jhan, R. Rempel, J. P. Rennhack, D. Hollern, L. Jackson, D. Judah, M. Swiatnicki, E. Bylett, R. Kubiak, J. Honeysett, S. Reaz, J. R. Nevins, E. R. Andrechek

This study investigates the role of E2F5 in mammary gland development and tumor prevention using a mouse model, finding that its loss leads to dysregulated Cyclin D1 and metastatic breast tumors.

bioRxiv · Sep 24, 2021 · PreprintCancer Biology

Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH

M. R. Swiatnicki, J. P. Rennhack, D. Hollern, A. V. Perry, R. Kubiak, S. M. Riveria Riveria, S. O'Reilly, E. R. Andrechek

This paper shows that PTPRH mutations in NSCLC lead to elevated EGFR phosphorylation, which can be targeted by existing EGFR inhibitors.

bioRxiv · Sep 14, 2021Cancer Biology

Low E2F2 activity is associated with high genomic instability and PARPi resistance

J. Rennhack, E. R. Andrechek

This paper identifies E2F2's role in genomic stability and PARPi resistance in breast cancer through bioinformatics and drug screening.

bioRxiv · Oct 3, 2019Cancer Biology

E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration

D. P. Hollern, M. R. Swiatnicki, J. P. Rennhack, S. A. Misek, B. C. Matson, A. McAuliff, K. A. Gallo, K. M. Caron, E. R. Andrechek

This study identifies E2F1 as a master regulator of metastasis by upregulating Fgf13, which promotes breast cancer cell migration and pulmonary metastasis.

bioRxiv · Jun 13, 2019Cancer Biology