The development and characterization of an scFv-Fc fusion based gene therapy to reduce the psychostimulant effects of methamphetamine abuse
C. E. Hay, L. E. Ewing, M. D. Hambuchen, S. M. Zintner, J. C. Small, C. T. Bolden, W. E. Fantegrossi, P. Margaritis, S. M. Owens, E. C. Peterson
This paper develops and tests an scFv-Fc fusion antibody gene therapy for reducing methamphetamine's psychostimulant effects in mice, showing dose-dependent efficacy in locomotor and biodistribution studies.
bioRxiv · Jun 29, 2019Pharmacology & Toxicology