S. M. Owens

Intrinsic p53 Activation Restricts Gammaherpesvirus-Driven Germinal Center B Cell Expansion during Latency Establishment

This study shows that p53 activation restricts MHV68-driven GC B cell expansion during latency, with M2 and LMP1 triggering p53-dependent anti-proliferative responses.

Replication-dead gammaherpesvirus vaccine protects against acute replication, reactivation from latency, and lethal challenge in mice

This paper develops a replication-dead gammaherpesvirus vaccine that protects mice from acute replication, reactivation, and lethal disease caused by wild-type virus.

B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an in vivo competition model

This study shows that B cell-intrinsic STAT3 supports gammaherpesvirus latency and suppresses interferon responses in mice, using a competitive infection model.

Inhibition of Microbial Methane Oxidation by 2-Chloro-6-Methylpyridine

This study examines how 2-chloro-6-methylpyridine affects aerobic methane oxidation and methanotroph populations in sediment.

Lytic Replication and Reactivation from B cells Is Not Required for Maintaining Gammaherpesvirus Latency in vivo

This study shows that lytic replication and reactivation in B cells are not required for maintaining gammaherpesvirus latency in vivo, as latency was preserved despite ORF50 deletion.

Deletion of Murine Gammaherpesvirus Gene M2 in AID-Expressing B Cells Impairs Host Colonization and Viral Reactivation

This study deletes the M2 gene in AID-expressing B cells of MHV68 and shows it impairs viral reactivation and host colonization.

p53 Controls Murine Gammaherpesvirus Latency and Prevents Infection-Associated IgH/c- Myc Translocations

This study shows that p53 restricts MHV68 latency establishment and prevents infection-associated genomic instability in mice.

Wetland plant evolutionary history influences soil and endophyte microbial community composition

The paper investigates how plant evolutionary history affects soil and endophyte microbial communities in wetlands, finding correlations between plant phylogeny and microbial composition.

Evaluation of DNA extraction protocols from liquid-based cytology specimens for studying cervical microbiota

This study evaluates DNA extraction protocols from liquid-based cytology specimens to assess their ability to capture cervical microbiota diversity, finding that all protocols provided equivalent accessibility with significant individual variation over storage.

The development and characterization of an scFv-Fc fusion based gene therapy to reduce the psychostimulant effects of methamphetamine abuse

This paper develops and tests an scFv-Fc fusion antibody gene therapy for reducing methamphetamine's psychostimulant effects in mice, showing dose-dependent efficacy in locomotor and biodistribution studies.

Community dynamics in parallelized, aerobic, single carbon-source enrichments

This study uses parallelized substrate arrays to examine how microbial communities respond to carbon amendments, finding that inoculum source strongly influences community composition despite divergence from the original community.