Corticosteroids and cellulose purification improve respectively the in vivo translation and vaccination efficacy of self-amplifying mRNAs
Z. Zhong, S. Mc Cafferty, L. Opsomer, H. Wang, H. Huysmans, J. De Temmerman, S. Lienenklaus, J. P. Portela Catani, F. Combes, N. Sanders
This study shows that corticosteroids and cellulose purification enhance sa-mRNA translation and vaccination efficacy by reducing innate immune responses.
bioRxiv · Aug 26, 2020Immunology