Lidocaine Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Cells Through Activation of Bitter Taste Receptor T2R14
Z. A. Miller, A. Mueller, J. F. Jolivert, R. Z. Ma, S. Muthuswami, A. Park, D. B. McMahon, R. M. Carey, R. J. Lee
This study shows lidocaine activates T2R14 in HNSCC cells, leading to apoptosis via mitochondrial depolarization, ROS production, and proteasome inhibition.
bioRxiv · Nov 22, 2022Cancer Biology