R. M. Carey

Lidocaine Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Cells Through Activation of Bitter Taste Receptor T2R14

This study shows lidocaine activates T2R14 in HNSCC cells, leading to apoptosis via mitochondrial depolarization, ROS production, and proteasome inhibition.

Taste receptor T1R3 in nasal cilia detects Staphylococcus aureus D-amino acids to increase apical glucose uptake and enhance innate immunity

The paper shows that T1R3 in nasal cilia detects D-amino acids from Staphylococcus aureus to reduce airway surface liquid glucose and enhance innate immunity.

Bitter taste receptor-stimulated nitric oxide innate immune responses are reduced by loss of CFTR function in nasal epithelial cells and macrophages

This study shows that loss of CFTR function reduces T2R-stimulated NO production in nasal epithelial cells and macrophages, impairing immune responses to gram-negative bacteria.

HSP90 modulates T2R bitter taste receptor nitric oxide production and innate immune responses in human airway epithelial cells and macrophages

This study shows HSP90 regulates T2R-dependent NO production and innate immune responses in airway cells, enhancing antibacterial defenses.

T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma

This study shows T2R bitter taste receptors in HNSCC promote apoptosis and are linked to better patient survival.

The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells

This study shows T2R agonists induce apoptosis in non-ciliated airway cells through nuclear calcium and mitochondrial pathways, potentially as a defense against infection or a risk in disease.

Altered polarization of PAR-2 signaling during airway epithelial remodeling

The paper examines how PAR-2 signaling polarization changes in airway epithelial cells during remodeling, finding increased apical responses in squamous metaplasia and loss of cilia.