CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter
H. Prizant, N. Patil, S. Negatu, A. McGurk, S. A. Leddon, A. Hughson, T. D. McRae, Y. Gao, A. M. Livingstone, J. R. Groom, A. D. Luster, D. J. Fowell
The paper identifies CXCL10+ perivascular clusters as Th1 activation niches that enhance T cell-APC interactions through IFN-gamma-dependent feedback.
bioRxiv · Oct 4, 2020Immunology