N. Patil

Supercharging carbohydrate-binding module alone enhances endocellulase thermostability, binding, and activity on cellulosic biomass

This study shows that supercharging carbohydrate-binding modules enhances endocellulase activity, thermostability, and performance on cellulosic biomass.

A comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

The paper develops and validates a method to simulate speckle contrast signals for optical blood flow measurements, revealing how detector effects impact accuracy and precision.

Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy

This paper develops automated tumor immunophenotyping pipelines to predict clinical benefit from anti-PD-L1 therapy in NSCLC and TNBC patients.

The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma

The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.

Interactions of surfactants with the bacterial cell wall and inner membrane: Revealing the link between aggregation and antimicrobial activity

This study investigates how surfactants interact with bacterial cell walls and membranes, showing that laurate is more effective than oleate in disrupting bacterial membranes and inducing aggregation.

CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter

The paper identifies CXCL10+ perivascular clusters as Th1 activation niches that enhance T cell-APC interactions through IFN-gamma-dependent feedback.

FAM13A regulates KLRG1 expression and interferon gamma production of natural killer cells

This study shows that FAM13A depletion increases KLRG1 and reduces IFN-gamma production in NK cells, leading to increased lung metastases in a mouse model.

Biomechanical Regulation of Breast Cancer Metastasis and Progression

This study investigates how mechanical forces affect breast cancer cell behavior, finding that tension alters gene expression, increases chemoresistance, and promotes metastasis through specific signaling pathways.