Real-time observation of flexible domain movements in Cas9
S. Osuka, K. Isomura, S. Kajimoto, T. Komori, H. Nishimasu, T. Shima, O. Nureki, S. Uemura
This study uses single-molecule FRET to observe dynamic domain movements in Cas9, showing flexibility enables DNA cleavage and sgRNA assembly.
bioRxiv · Sep 15, 2017Biophysics