Author

T. Komori

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Mabuchi· 2 shared D. Kitagawa· 2 shared M. Fukuyama· 2 shared M. Genova· 2 shared S. Hata· 2 shared T. Chinen· 2 shared A. Toyoda· 1 shared C. Tei· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

A. Mabuchi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ssDNA is not superior to dsDNA as long HDR donors for CRISPR-mediated endogenous gene tagging in human diploid cells

A. Mabuchi, S. Hata, M. Genova, C. Tei, K. K. Ito, M. Hirota, T. Komori, M. Fukuyama, T. Chinen, A. Toyoda, D. Kitagawa

This study compares ssDNA and dsDNA as HDR donors for CRISPR-mediated gene tagging in human diploid cells, finding dsDNA more efficient for precise insertion.

bioRxiv · Jun 1, 2022 · PreprintCell Biology

A CRISPR-del-based pipeline for complete gene knockout in human diploid cells

T. Komori, S. Hata, A. Mabuchi, M. Genova, T. Harada, M. Fukuyama, T. Chinen, D. Kitagawa

This study introduces a CRISPR-del pipeline to achieve complete gene knockout in human diploid cells by inducing large chromosomal deletions, showing higher efficiency than conventional methods.

bioRxiv · Jun 21, 2021Cell Biology

The oncogenic Runx3-Myc axis defines p53-deficient osteosarcomagenesis

S. Otani, Y. Date, T. Ueno, T. Ito, S. Kajikawa, K. Omori, I. Taniuchi, M. Umeda, T. Komori, J. Toguchida, K. Ito

This study identifies the Runx3-Myc axis as a driver of p53-deficient osteosarcomagenesis in human and mouse models.

bioRxiv · May 3, 2021 · PreprintCancer Biology

Real-time observation of flexible domain movements in Cas9

S. Osuka, K. Isomura, S. Kajimoto, T. Komori, H. Nishimasu, T. Shima, O. Nureki, S. Uemura

This study uses single-molecule FRET to observe dynamic domain movements in Cas9, showing flexibility enables DNA cleavage and sgRNA assembly.

bioRxiv · Sep 15, 2017Biophysics