BiophysicsbioRxiv
Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling
G. L. Lukacs, N. Soya, H. Xu…·T. Hegedus
The paper shows that allosteric domain-domain coupling modulates the folding landscape of ABCC transporters, and that folding correctors can rescue misfolding by rewiring these networks.
DOI 10.1038/s41467-023-42586-8