T. Hegedus

SARS CoV-2 Envelope protein alters calcium signaling via SERCA interactions

This study shows that SARS-CoV-2 E protein interacts with SERCA2b and regulins, altering calcium homeostasis and potentially contributing to viral pathogenesis.

A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity

The paper shows that mutation of L704 in ABCG36 affects substrate specificity by altering transport of IBA and CLX, with molecular dynamics supporting a quality control role.

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling

The paper shows that allosteric domain-domain coupling modulates the folding landscape of ABCC transporters, and that folding correctors can rescue misfolding by rewiring these networks.

Nanomechanics combined with HDX reveal allosteric drug binding sites of CFTR NBD1

This study combines nanomechanics and HDX to identify allosteric binding sites in {Delta}F508-CFTR NBD1, revealing how BIA stabilizes the protein.

Mechanism of non-blocking inhibition of sodium channels revealed by conformation-selective photolabeling

This study reveals that riluzole inhibits sodium channels through non-blocking modulation rather than block, using conformation-selective photolabeling to identify binding sites and mechanisms.