Author

J. C. Kappes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Assay:flow cytometry· 1

Frequent Co-Authors

H. Ding· 3 shared A. B. Smith· 2 shared A. Finzi· 2 shared B. H. Hahn· 2 shared F. Jiang· 2 shared F. Kirchhoff· 2 shared G. L. Lukacs· 2 shared G. Veit· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMicrobiology

H. Ding

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling

G. L. Lukacs, N. Soya, H. Xu, A. Roldan, Z. Yang, H. Ye, A. Premchandar, F. Jiang, G. Veit, S. P. C. Cole, J. C. Kappes, T. Hegedus

The paper shows that allosteric domain-domain coupling modulates the folding landscape of ABCC transporters, and that folding correctors can rescue misfolding by rewiring these networks.

bioRxiv · Oct 19, 2023Biophysics

Conformations of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles (SMALPs)

R. Zhou, S. Zhang, H. T. Nguyen, H. Ding, A. Gaffney, J. C. Kappes, A. B. Smith, J. G. Sodroski

This study compares the stability and conformation of HIV-1 Env in detergents versus SMA lipids, showing SMA preserves the pretriggered state better at room temperature.

bioRxiv · Mar 1, 2023 · PreprintMicrobiology

Mechanism of dual pharmacological correction and potentiation of human CFTR

C. Wang, Z. Yang, B. J. Loughlin, H. Xu, G. Veit, S. Vorobiev, O. B. Clarke, F. Jiang, Y. Li, S. Singh, Z. Rich, E. R. Menten, R. A. Grassucci, W. Wang, A. Mezzell, , J. F. Hunt

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

bioRxiv · Oct 10, 2022 · PreprintBiophysics

Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity

A. Laumaea, L. Marchitto, G. Beaudoin-Bussieres, S. Ding, R. Gasser, D. Chatterjee, G. Gendron-Lepage, H. Medjahed, H.-C. Chen, A. B. Smith, H. Ding, J. C. Kappes, B. H. Hahn, F. Kirchhoff, J. Richard, , A. Finzi

The paper shows that small CD4 mimetics expose ADCC epitopes on HIV-1-infected macrophages, making them susceptible to antibody-dependent cellular cytotoxicity.

bioRxiv · Jun 30, 2022Microbiology

Detection of the HIV-1 accessory proteins Nef and Vpu by flow cytometry represents a new tool to study their functional interplay within a single infected CD4+ T cell

J. Prevost, J. Richard, R. Gasser, H. Medjahed, F. Kirchhoff, B. H. Hahn, J. C. Kappes, C. Ochsenbauer, R. Duerr, A. Finzi

The paper develops a flow cytometry method to detect HIV-1 Nef and Vpu in CD4+ T cells, showing Vpu cannot compensate for Nef absence in ADCC susceptibility.

bioRxiv · Nov 3, 2021Microbiology

Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects

H. T. Nguyen, S. Zhang, Q. Wang, S. Anang, J. Wang, H. Ding, J. C. Kappes, J. G. Sodroski

This study identifies key features of the SARS-CoV-2 spike glycoprotein, including the furin cleavage site and D614G mutation, that influence viral infectivity, stability, and cytopathicity.

bioRxiv · Oct 22, 2020Microbiology