G. L. Lukacs

SARS CoV-2 Envelope protein alters calcium signaling via SERCA interactions

This study shows that SARS-CoV-2 E protein interacts with SERCA2b and regulins, altering calcium homeostasis and potentially contributing to viral pathogenesis.

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling

The paper shows that allosteric domain-domain coupling modulates the folding landscape of ABCC transporters, and that folding correctors can rescue misfolding by rewiring these networks.

HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins

This study identifies HERC3 as a cytosolic E3 ligase that facilitates ERAD of specific polytopic membrane proteins like CFTR, distinct from RNF5/185.

Mechanism of dual pharmacological correction and potentiation of human CFTR

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes

This study shows that Keratin 8 modulates ERAD complexes, enhancing degradation of misfolded proteins like Z-A1AT and F508del-CFTR, and suggests targeting K8 for therapeutic intervention in A1ATD.

Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting

The paper shows that transcytosis helps maintain CFTR apical polarity by retrieving basolateral CFTR and counteracting missorting caused by mutations or loss of NHERF1 interaction.