Extracellular Hsp90α Detoxifies β-Amyloid Fibrils Through an NRF2 and Autophagy Dependent Pathway
A. Murshid, B. J. Lang, T. J. Borges, Y. Okusha, S. P. Doshi, S. Yasmine, J. Clark-Matott, R. Choudhury, L.-H. Ang, M. Woodbury, T. Ikezu, S. K. Calderwood
This study shows eHsp90 reduces neuronal toxicity from f-Aβ1-42 by activating NRF2-mediated autophagy in microglia.
bioRxiv · Apr 16, 2021 · PreprintCell Biology