R. Choudhury

The role of RNA in the maintenance of chromatin domains as revealed by antibody mediated proximity labelling coupled to mass spectrometry

The paper introduces AMPL-MS to study chromatin domains in Drosophila, showing RNA's role in maintaining their proteomic composition.

The BOD1L subunit of the SETD1A complex sustains the expression of DNA damage repair genes despite restraining H3K4 trimethylation

The paper shows that BOD1L in the SETD1A complex maintains DNA repair gene expression despite reducing H3K4 trimethylation, and its loss causes DNA damage and cell death in ESCs.

A core transcriptional response for biofilm formation by Y. pseudotuberculosis

This study identifies a core set of genes involved in biofilm formation by Y. pseudotuberculosis across different inducing conditions and shows their functional roles in biofilm development.

RpoN is required for a functional type III secretion system in Yersinia pseudotuberculosis

This study shows that RpoN is essential for Type III secretion in Yersinia pseudotuberculosis by regulating the expression of secretion apparatus genes through a sigma factor hierarchy involving RpoE.

Extracellular Hsp90α Detoxifies β-Amyloid Fibrils Through an NRF2 and Autophagy Dependent Pathway

This study shows eHsp90 reduces neuronal toxicity from f-Aβ1-42 by activating NRF2-mediated autophagy in microglia.

The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation in Drosophila

This study identifies a six-subunit Speciation Core Complex containing Hmr and Lhr, showing Hmr's role in centromeric binding and hybrid male lethality in Drosophila.

Early-life feeding accelerates gut microbiome maturation in piglets

This study shows that early feeding with a fibrous diet accelerates gut microbiome maturation in piglets, increasing microbial diversity and promoting post-weaning microbial groups earlier.

FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress

This study shows FHL-1 protects RPE cells from oxidative stress via α5β1 integrin interaction, with increased heat-shock protein expression and improved cell survival.

Genome-scale mapping reveals complex regulatory activities of RpoN in Yersinia pseudotuberculosis

This study maps RpoN's genome-wide regulatory activities in Yersinia pseudotuberculosis, revealing its role in virulence, biofilm formation, and gene regulation through binding sites and mutagenesis.

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

The paper predicts APC/C substrates in silico, identifies chromatin regulators as substrates, and shows their cell cycle-dependent degradation and impact on DNA methylation.

The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylation

This paper shows that the yeast Set1 complex is dimeric, leading to symmetric H3K4me3, and that Jhd2 demethylase removes asymmetric H3K4me3, working together to establish epigenetic symmetry.