Modulation of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc
G. W. D. Easson, A. Savadipour, A. Anandarajah, L. E. Iannucci, S. P. Lake, F. Guilak, S. Y. Tang
This study shows TRPV4 activation protects intervertebral discs from mechanical loading-induced degeneration by enhancing matrix synthesis and reducing inflammation.
bioRxiv · Nov 18, 2022Pathology