Author

F. Guilak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 3 Bioengineering· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:differential expression· 3 Approach:genetic perturbation / CRISPR· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

R. Tang· 4 shared C.-L. Wu· 3 shared C. C. Gloss· 2 shared Y.-R. Choi· 2 shared A. Anandarajah· 1 shared A. Dicks· 1 shared A. K. Oestreich· 1 shared A. McAlinden· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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4 shared papersPhysiology

R. Tang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Designer Fat Cells: Adipogenic Differentiation of CRISPR-Cas9 Genome-Engineered Induced Pluripotent Stem Cells

E. V. Ely, A. T. Kapinski, S. G. Paradi, R. Tang, F. Guilak, K. H.-M. Collins

This paper develops a method to generate genetically engineered adipocytes from murine iPSCs using CRISPR-Cas9 and tests their engraftment and functional properties in vivo.

bioRxiv · Oct 26, 2023 · PreprintBioengineering

Modulation of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc

G. W. D. Easson, A. Savadipour, A. Anandarajah, L. E. Iannucci, S. P. Lake, F. Guilak, S. Y. Tang

This study shows TRPV4 activation protects intervertebral discs from mechanical loading-induced degeneration by enhancing matrix synthesis and reducing inflammation.

bioRxiv · Nov 18, 2022Pathology

Aging and Obesity Prime the Methylome and Transcriptome of Adipose Stem Cells for Disease and Dysfunction

S. Xie, S. Choudhari, C.-L. Wu, K. Abramson, D. Corcoran, S. G. Gregory, J. M. Thimmapuram, F. Guilak, D. Little

This study identifies epigenetic and transcriptomic changes in adipose stem cells due to aging and obesity, revealing synergistic effects and potential disease-related regulators.

bioRxiv · Sep 26, 2022Cell Biology

Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks

M. Dudek, D. Pathiranage, C. F. Goncalves, C. Lawless, D. Wang, Z. Luo, L. Yang, F. Guilak, J. A. Hoyland, Q.-J. Meng

The paper shows mechanical loading and hyperosmolarity reset circadian clocks in skeletal tissues via the mTORC2-AKT-GSK3β pathway, inducing rhythmic gene expression.

bioRxiv · Oct 1, 2021Physiology

Adipose Tissue is a Critical Regulator of Osteoarthritis

K. H. Collins, K. L. Lenz, E. N. Pollitt, D. Ferguson, I. Hutson, L. E. Springer, A. K. Oestreich, R. Tang, Y.-R. Choi, G. A. Meyer, S. L. Teitelbaum, C. T. N. Pham, C. A. Harris, F. Guilak

This study shows adipose tissue, not body weight, drives osteoarthritis progression through paracrine signaling in a mouse model of lipodystrophy.

bioRxiv · Jun 4, 2020Physiology

Long non-coding RNA GRASLND enhances chondrogenesis via suppression of interferon type II signaling pathway

N. P. Huynh, C. C. Gloss, J. Lorentz, R. Tang, A. McAlinden, B. Zhang, J. Brunger, F. Guilak

This study identifies GRASLND as a primate-specific lncRNA that enhances chondrogenesis by suppressing interferon type II signaling in mesenchymal stem cells.

eLife · Mar 23, 2020Peer-reviewedCell Biology

Prospective Isolation of Chondroprogenitors from Human iPSCs Based on Cell Surface Markers Identified using a CRISPR-Cas9-Generated Reporter

A. Dicks, C.-L. Wu, N. Steward, S. S. Adkar, C. A. Gersbach, F. Guilak

The paper identifies and isolates a novel chondroprogenitor subpopulation from hiPSCs using surface markers and CRISPR-Cas9 reporter technology, showing enhanced chondrogenic potential.

bioRxiv · Jun 19, 2019Cell Biology

Gene Therapy for Follistatin Mitigates Systemic Metabolic Inflammation and Post-Traumatic Osteoarthritis in High-Fat Diet-Induced Obese Mice

R. Tang, N. Harasymowicz, C.-L. Wu, K. Collins, Y.-R. Choi, S. Oswald, F. Guilak

This study shows that FST gene therapy reduces metabolic inflammation and post-traumatic OA in obese mice by improving mitochondrial function and adipose tissue browning.

bioRxiv · Apr 25, 2019Physiology

Regulation of Decellularized Tissue Remodeling via Scaffold-Mediated Lentiviral Delivery in Anatomically-Shaped Osteochondral Constructs

C. Rowland, K. A. Glass, A. R. Ettyreddy, C. C. Gloss, J. Matthews, N. P. T. Huynh, F. Guilak

This study uses scaffold-mediated lentiviral delivery to control inflammation and tissue formation in osteochondral constructs.

bioRxiv · Feb 8, 2018Bioengineering