Reduced Shmt2 expression impairs mitochondrial folate accumulation and respiration, and leads to uracil accumulation in mouse mitochondrial DNA
J. L. Fiddler, Y. Xiu, J. E. Blum, S. G. Lamarre, W. N. Phinney, S. P. Stabler, M. E. Brosnan, J. T. Brosnan, A. E. Thalacker-Mercer, M. S. Field
This study shows that reduced Shmt2 expression and folate deficiency impair mitochondrial dTMP synthesis, increase uracil in mtDNA, and reduce mitochondrial function in mice.
bioRxiv · Apr 12, 2021Biochemistry