M. S. Field

C2C12 muscle myotubes, but not kidney proximal tubule HK-2 cells, elevate erythritol synthesis in response to oxidative stress

The paper shows that C2C12 muscle cells increase erythritol synthesis under high glucose and oxidative stress, while HK-2 kidney cells only respond to high glucose.

Elevated plasma and urinary erythritol is a biomarker of excess simple carbohydrate intake in mice

This study shows that sucrose intake, not high-fat diet, increases plasma and urinary erythritol in mice, while loss of SORD or ADH1 does not significantly affect erythritol levels.

Reduced methionine synthase (Mtr) expression creates a functional vitamin B12 deficiency that leads to uracil accumulation in mouse mitochondrial DNA

This study shows that reduced Mtr expression causes B12 deficiency, leading to uracil accumulation in mtDNA and impaired mitochondrial function in mice.

Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

This study shows reduced SHMT2 expression or folate availability impairs mitochondrial function, pyruvate kinase activity, and cellular proliferation in cell models.

Erythritol synthesis in human cells is elevated in response to oxidative stress and regulated by the non-oxidative pentose phosphate pathway

This study identifies that erythritol synthesis in human cells is elevated under oxidative stress and regulated by non-oxidative PPP enzymes.

Reduced Shmt2 expression impairs mitochondrial folate accumulation and respiration, and leads to uracil accumulation in mouse mitochondrial DNA

This study shows that reduced Shmt2 expression and folate deficiency impair mitochondrial dTMP synthesis, increase uracil in mtDNA, and reduce mitochondrial function in mice.

Chronic dietary erythritol exposure elevates fasting plasma erythritol levels but does not cause weight gain or modify glucose homeostasis in mice

This study shows chronic erythritol consumption in mice increases plasma erythritol levels but does not lead to weight gain or affect glucose tolerance.

Serine and glycine are essential for human muscle progenitor cell population expansion

This study identifies serine and glycine as essential for human muscle progenitor cell proliferation and shows their availability declines with age, impairing muscle regeneration.