Author

J. E. Blum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. E. Thalacker-Mercer· 4 shared M. S. Field· 3 shared J. L. Fiddler· 2 shared A. E. Qualls· 1 shared A. G. Schifino· 1 shared A. S. Nichenko· 1 shared B. D. Cosgrove· 1 shared B. J. Gheller· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiochemistry

A. E. Thalacker-Mercer

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4 papers

Recent·Most cited

Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

J. L. Fiddler, J. E. Blum, L. F. Castillo, A. E. Thalacker-Mercer, M. S. Field

This study shows reduced SHMT2 expression or folate availability impairs mitochondrial function, pyruvate kinase activity, and cellular proliferation in cell models.

bioRxiv · Apr 7, 2022 · PreprintBiochemistry

Reduced Shmt2 expression impairs mitochondrial folate accumulation and respiration, and leads to uracil accumulation in mouse mitochondrial DNA

J. L. Fiddler, Y. Xiu, J. E. Blum, S. G. Lamarre, W. N. Phinney, S. P. Stabler, M. E. Brosnan, J. T. Brosnan, A. E. Thalacker-Mercer, M. S. Field

This study shows that reduced Shmt2 expression and folate deficiency impair mitochondrial dTMP synthesis, increase uracil in mtDNA, and reduce mitochondrial function in mice.

bioRxiv · Apr 12, 2021Biochemistry

Lifelong Ulk1-mediated autophagy deficiency in muscle induces mitochondrial dysfunction and contractile weakness

A. S. Nichenko, J. R. Sorensen, W. M. Southern, A. E. Qualls, A. G. Schifino, J. McFaline-Figueroa, J. E. Blum, A. E. Thalacker-Mercer, S. M. Greising, J. A. Call

This study shows that lifelong Ulk1-mediated autophagy deficiency in muscle leads to mitochondrial dysfunction and contractile weakness in aging.

bioRxiv · Jul 31, 2020Physiology

Serine and glycine are essential for human muscle progenitor cell population expansion

B. J. Gheller, J. E. Blum, E. L. Bender, M. E. Gheller, E. W. Lim, M. K. Handzlik, P. J. Stover, M. S. Field, B. D. Cosgrove, C. M. Metallo, A. E. Thalacker-Mercer

This study identifies serine and glycine as essential for human muscle progenitor cell proliferation and shows their availability declines with age, impairing muscle regeneration.

bioRxiv · Nov 7, 2019 · PreprintCell Biology