Author

S. Pauklin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

F. Liu· 2 shared U. Oppermann· 2 shared A. G. Jegga· 1 shared A. Osnato· 1 shared A. Rendek· 1 shared C.-H. Chang· 1 shared D. Ahern· 1 shared D. Ortmann· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

F. Liu

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Author profile →

3 papers

Recent·Most cited

High-dimensional mass cytometry reveals stemness state heterogeneity in pancreatic ductal adenocarcinoma

E. H. Ervin, D. Ahern, F. Liu, A. Rendek, Z. Soonawalla, U. Oppermann, P. Hulley, S. Pauklin

The paper uses mass cytometry to analyze stemness states in PDAC, revealing molecular heterogeneity and identifying a subset with plastic phenotypes.

bioRxiv · Feb 27, 2024 · PreprintCancer Biology

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

Y. Feng, L. Cai, M. Pook, F. Liu, C.-H. Chang, M. A. Mouti, R. Nibhani, S. Wu, S. Deng, S. Militi, J. Dunford, M. Philpott, Y. Fan, G.-C. Fan, Q. Liu, , S. Pauklin

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

bioRxiv · Mar 2, 2023Cancer Biology

Epigenetic regulations follow cell cycle progression during differentiation of human pluripotent stem cells.

P. Madrigal, S. Pauklin, K. Jee Goh, R. Grandy, A. Osnato, D. Ortmann, L. Vallier, S. Brown

This study investigates epigenetic changes during the first two cell divisions of human pluripotent stem cell differentiation using synchronized cultures and identifies key regulatory mechanisms.

bioRxiv · Jun 26, 2020Cell Biology