Author

A. G. Jegga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:metabolomics· 2 Organism:mouse· 2

Frequent Co-Authors

Y. Wang· 3 shared C. Gao· 2 shared D. Chen· 2 shared J. Kravitz· 2 shared V. Nguyen· 2 shared W. Tan· 2 shared A. Kuenzi· 1 shared C. Wenceslau· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

Y. Wang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells

V. Nguyen, J. Kravitz, C. Gao, M. L. Hochman, D. Meng, D. Chen, Y. Wang, A. G. Jegga, S. Nelson, W. Tan

This study identifies metabolic perturbations in PWB-derived iPSCs, showing upregulated glutathione and downregulated sphingolipid metabolism, which may contribute to laser resistance in PWB vasculature.

bioRxiv · Jul 18, 2023 · PreprintCell Biology

Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

V. Nguyen, C. Gao, M. Hochman, J. Kravitz, E. Chen, H. Friedman, C. Wenceslau, D. Chen, Y. Wang, J. S. Nelson, A. G. Jegga, W. Tan

This study generates iPSCs from PWB fibroblasts and differentiates them into ECs that recapitulate disease phenotypes, identifying dysregulated pathways and genes involved in vascular malformations.

bioRxiv · Jul 2, 2023 · PreprintCell Biology

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

Y. Feng, L. Cai, M. Pook, F. Liu, C.-H. Chang, M. A. Mouti, R. Nibhani, S. Wu, S. Deng, S. Militi, J. Dunford, M. Philpott, Y. Fan, G.-C. Fan, Q. Liu, , S. Pauklin

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

bioRxiv · Mar 2, 2023Cancer Biology

Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity

K. W. Kalim, J.-Q. Yang, M. Wunderlich, V. Modur, P. Nguyen, Y. Li, T. Wen, A. Kuenzi, R. Verma, Q. R. Lu, A. G. Jegga, Y. Zheng, F. Guo

This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.

bioRxiv · Sep 23, 2021 · PreprintImmunology

The loss of IL-31 signaling attenuates bleomycin-induced pulmonary fibrosis

D. J. Yombo, V. Odayar, N. Gupta, A. G. Jegga, S. K. Madala

This study shows that blocking IL-31 signaling reduces collagen deposition and lung function decline in bleomycin-induced pulmonary fibrosis.

bioRxiv · Dec 18, 2020 · PreprintImmunology