Xylazine co-self-administration suppresses fentanyl consumption during self-administration and induces a unique sex-specific withdrawal syndrome that is not altered by naloxone in rats
S. N. Khatri, S. Sadek, P. T. Kendrick, E. O. Bondy, M. Hong, S. Pauss, D. Luo, T. Prisinzano, K. E. Dunn, J. A. Marusich, J. Beckmann, T. Hinds, C. D. Gipson
This study shows that xylazine reduces fentanyl self-administration in rats and causes sex-specific withdrawal symptoms not affected by naloxone.
bioRxiv · May 17, 2023 · PreprintAnimal Behavior & Cognition