S. Piacentini

Human coronaviruses activate and hijack the proteostasis guardian HSF1 to enhance viral replication

This study shows that human coronaviruses activate HSF1 to enhance replication, suggesting HSF1 as a potential antiviral target.

The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoprotein

The paper shows nitazoxanide inhibits seasonal coronaviruses by interfering with spike glycoprotein maturation, not affecting viral entry.

Impairment of SARS-CoV-2 spike-glycoprotein maturation and fusion-activity by nitazoxanide: an effect independent of spike variants emergence

This study shows nitazoxanide impairs SARS-CoV-2 spike maturation and fusion activity, effective against multiple variants including Delta.