Cell BiologybioRxiv
KRASG12D mutant cells are outcompeted by wild type neighbours in adult pancreas in an EPHA2-dependent manner.
W. Hill, A. Zaragkoulias, B. Salvador…·C. Hogan
This study shows that KRASG12D mutant cells are outcompeted by wild-type cells in the adult pancreas, dependent on EphA2 signaling, leading to tissue clearance and reduced premalignant lesions.