Author

M. Alatsatianos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

O. J. Sansom· 3 shared C. Hogan· 2 shared J. P. Morton· 2 shared A. Ager· 1 shared A. Dritsoula· 1 shared A. H. Watson· 1 shared A. Padilha· 1 shared A. Zaragkoulias· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

O. J. Sansom

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3 papers

Recent·Most cited

Oncogenic KRAS cells use Wnt signalling and cell dormancy to override homeostatic cell elimination mechanisms in adult pancreas.

B. Salvador-Barbero, M. Alatsatianos, J. P. Morton, O. J. Sansom, C. Hogan

This study shows that oncogenic KRAS cells in the adult pancreas evade elimination by using Wnt signaling and cell dormancy.

bioRxiv · Feb 13, 2024Cell Biology

LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency

M. N. O'Connor, D. M. Kallenberg, R. Jackstadt, A. H. Watson, M. Alatsatianos, J. Ohme, C. Camilli, C. Pilotti, A. Dritsoula, C. E. Bowers, L. Dowsett, J. George, X. Wang, A. Ager, O. J. Sansom, , J. Greenwood

This study shows that LRG1 promotes tumor vascular dysfunction and suppresses immunotherapy effectiveness, with its inhibition enhancing therapeutic outcomes in mouse cancer models.

bioRxiv · Oct 12, 2020Cancer Biology

KRASG12D mutant cells are outcompeted by wild type neighbours in adult pancreas in an EPHA2-dependent manner.

W. Hill, A. Zaragkoulias, B. Salvador, G. Parfitt, M. Alatsatianos, A. Padilha, S. Porazinski, T. E. Woolley, J. P. Morton, O. J. Sansom, C. Hogan

This study shows that KRASG12D mutant cells are outcompeted by wild-type cells in the adult pancreas, dependent on EphA2 signaling, leading to tissue clearance and reduced premalignant lesions.

bioRxiv · Aug 4, 2020Cell Biology