J. P. Morton

Oncogenic KRAS cells use Wnt signalling and cell dormancy to override homeostatic cell elimination mechanisms in adult pancreas.

This study shows that oncogenic KRAS cells in the adult pancreas evade elimination by using Wnt signaling and cell dormancy.

KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo

This study shows that wild-type KRAS suppresses tumour growth and metastasis in KRAS mutant colorectal cancer while enhancing resistance to MEK inhibition.

Kras loss of heterozygosity promotes MAPK dependent pancreatic ductal adenocarcinoma and induces therapeutic sensitivity

This study shows that loss of wild-type Kras enhances oncogenic Kras signaling and promotes pancreatic ductal adenocarcinoma, while also increasing sensitivity to MEK1/2 inhibitors.

Human skeletal muscle methylome after low carbohydrate energy balanced exercise

This study examines DNA methylation changes in human skeletal muscle after low carbohydrate exercise under energy balance and deficit conditions, identifying hypomethylation in gene regions linked to metabolic pathways.

βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer

This study identifies βIII-tubulin as a suppressor of extrinsic apoptosis in pancreatic cancer, showing that its silencing enhances sensitivity to death signals and reduces tumor progression.

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

This study shows that extracellular adenosine promotes an immunosuppressive microenvironment in PDAC by enhancing myeloid cell infiltration and resistance to immunotherapy, and that blocking adenosine pathway components improves therapeutic outcomes.

Maturation, developmental site, and pathology dictate murine neutrophil function

This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.

Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis.

This study identifies IQSEC1 variants that spatially regulate phosphoinositide metabolism to switch cell behavior from growth to invasion, with implications for metastasis.

KRASG12D mutant cells are outcompeted by wild type neighbours in adult pancreas in an EPHA2-dependent manner.

This study shows that KRASG12D mutant cells are outcompeted by wild-type cells in the adult pancreas, dependent on EphA2 signaling, leading to tissue clearance and reduced premalignant lesions.

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.

This study identifies TLR2 as a key mediator of oncogene-induced senescence by promoting cell cycle arrest and regulating the senescence-associated secretory phenotype through DAMPs.

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

This study shows macrophages in pancreatic cancer release pyrimidines that inhibit gemcitabine therapy by competing with the drug for uptake and metabolism, and reducing macrophage burden improves treatment response.