CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis
S. Mohanty, P. Mohapatra, O. Shriwas, M. Priyadarshini, S. A. Ansari, S. Priyadarsini, R. Rath, M. Sultania, S. K. Das Majumdar, R. Dash
The paper identifies MINK1 as a key driver of 5FU resistance in OSCC using CRISPR screening and shows that lestaurtinib can restore 5FU sensitivity.
bioRxiv · Aug 19, 2021Cancer Biology