Design of stimulus-responsive two-state hinge proteins
F. Praetorius, P. J. Y. Leung, M. H. Tessmer, A. Broerman, C. Demakis, A. F. Dishman, A. Pillai, A. Idris, D. Juergens, J. Dauparas, X. Li, P. M. Levine, M. Lamb, R. K. Ballard, S. R. Gerben, , D. Baker
This paper designs two-state hinge proteins that switch between structural states in response to ligands, demonstrating atomic-level accuracy and tunable kinetics and thermodynamics.
bioRxiv · Jan 27, 2023Biophysics