Author

A. Idris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Bioengineering· 2 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 4 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. Supramaniam· 3 shared A. Broerman· 2 shared A. Pillai· 2 shared C. Demakis· 2 shared D. Baker· 2 shared F. Praetorius· 2 shared G. Kelly· 2 shared N. A. McMillan· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. Supramaniam

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

De novo design of allosterically switchable protein assemblies

A. Pillai, A. Idris, A. Philomin, C. Weidle, R. Skotheim, P. J. Y. Leung, A. Broerman, C. Demakis, A. J. Borst, F. Praetorius, D. Baker

This paper designs allosterically switchable protein assemblies using rigid-body coupling of effector-switchable modules, demonstrating cooperative ligand binding and structural changes similar to natural systems.

bioRxiv · Nov 1, 2023Biochemistry

ACE2-Coated Virus-Like Particles Effectively Block SARS-CoV-2 Infection

C. Bayraktar, A. Kayabolen, A. Odabas, A. Durgun, I. Kok, K. Sevinc, A. Supramaniam, A. Idris, T. Bagci-Onder

This paper develops ACE2-coated virus-like particles (ACE2-VLPs) that effectively neutralize SARS-CoV-2, including variants, and show superior efficacy compared to ACE2-expressing extracellular vesicles.

bioRxiv · Sep 19, 2023 · PreprintBioengineering

Design of stimulus-responsive two-state hinge proteins

F. Praetorius, P. J. Y. Leung, M. H. Tessmer, A. Broerman, C. Demakis, A. F. Dishman, A. Pillai, A. Idris, D. Juergens, J. Dauparas, X. Li, P. M. Levine, M. Lamb, R. K. Ballard, S. R. Gerben, , D. Baker

This paper designs two-state hinge proteins that switch between structural states in response to ligands, demonstrating atomic-level accuracy and tunable kinetics and thermodynamics.

bioRxiv · Jan 27, 2023Biophysics

Intranasal delivery of lipid nanoparticle encapsulated SARS-CoV-2 and RSV-targeting siRNAs reduces lung infection

A. Supramaniam, Y. Tayyar, D. T. Clarke, G. Kelly, K. V. Morris, N. A. McMillan, A. Idris

This paper develops an intranasal lipid nanoparticle (LNP) delivery system for siRNAs targeting SARS-CoV-2 and RSV, showing effective reduction of lung infection in mice.

bioRxiv · Jul 25, 2022 · PreprintMicrobiology

Simple visualization of submicroscopic protein clusters with a phase-separation-based fluorescent reporter.

T. R. Mumford, D. Rae, E. Brackhahn, A. Idris, D. Gonzalez-Martinez, A. A. Pal, M. C. Chung, J. Guan, E. Rhoades, L. J. Bugaj

This paper introduces CluMPS, a fluorescent reporter that detects and amplifies submicroscopic protein clusters, enabling visualization of small oligomers and endogenous protein assemblies.

bioRxiv · Jul 13, 2022Bioengineering

Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine

C. L. D. McMillan, J. J. Y. Choo, A. Idris, A. Supramaniam, N. Modhiran, A. A. Amarilla, A. Isaacs, S. T. M. Cheung, B. Liang, H. Bielefeldt-Ohmann, A. Azuar, D. Acharya, G. Kelly, G. J. P. Fernando, M. J. Landsberg, , D. A. Muller

A single dose of a SARS-CoV-2 spike vaccine delivered via a high-density microarray patch provides complete protection against a lethal virus challenge.

bioRxiv · May 30, 2021Microbiology

Development of novel lipidic particles for siRNA delivery that are highly effective after 12 months storage

D. Clarke, A. Idris, N. A. McMillan

This study develops lipidic particles for siRNA delivery that remain effective after 12 months of storage at various temperatures.

bioRxiv · Aug 13, 2018Biochemistry