Effects of IL2/anti-IL2 antibody complex on chikungunya virus-induced arthritis in a mouse model
S. R. Tritsch, A. J. Porzucek, A. M. Schwartz, A. M. Proctor, R. Amdur, P. S. Latham, G. L. Simon, C. N. Mores, A. Y. Chang
The paper tests the effects of IL2/anti-IL2 antibody complex and anti-IL2 mAb on CHIKV arthritis in mice, finding that the complex increases IL2 and Tregs but also Teffs, while the antibody reduces disease scores by increasing IL2 availability.
bioRxiv · Jan 30, 2023Immunology