Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase
K. J. Mickolajczyk, P. M. M. Shelton, M. Grasso, X. Cao, S. R. Warrington, A. Aher, S. Liu, T. M. Kapoor
This study investigates the force-dependent unwinding activity of SARS-CoV-2 nsp13 helicase using optical tweezers, revealing increased unwinding frequency, processivity, and velocity under destabilizing force.
bioRxiv · Jul 31, 2020Biophysics