K. J. Mickolajczyk

Inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution.

This study uses nanopore tweezers to analyze SARS-CoV-2 helicase nsp13 motion and inhibition at single-nucleotide resolution, revealing kinetic mechanisms and inhibitor effects.

The MIDAS domain of AAA mechanoenzyme Mdn1 forms catch bonds with two different substrates

This study investigates how the MIDAS domain of Mdn1 forms catch bonds with two different UBL substrates under force, revealing force-dependent binding lifetime changes.

Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase

This study investigates the force-dependent unwinding activity of SARS-CoV-2 nsp13 helicase using optical tweezers, revealing increased unwinding frequency, processivity, and velocity under destabilizing force.

The Orphan Kinesin PAKRP2 Achieves Processive Motility Via Noncanonical Stepping

This study shows that PAKRP2, an orphan kinesin in Arabidopsis, moves processively along microtubules using a noncanonical stepping mechanism with small steps and lateral movements.

Direct observation of individual tubulin dimers binding to growing microtubules

The paper directly measures tubulin on- and off-rates at growing microtubule tips using interferometric scattering microscopy and computational modeling.

Measurement of the Persistence Length of Cytoskeletal Filaments using Curvature Distributions

The paper introduces a curvature distribution method to measure the persistence length of cytoskeletal filaments, showing it is more accurate for small datasets and applicable to both in vitro and in vivo data.

Motor reattachment kinetics play a dominant role in multimotor-driven cargo transport

This study investigates how motor reattachment kinetics influence multi-motor-driven cargo transport, finding that kinesin-2's faster reattachment rate enhances cargo movement and navigation.