convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting
K. Landgraf, S. R. Williams, D. Steiger, D. Gebhart, S. Lok, D. W. Martin, K. T. Roybal, K. C. Kim
This paper introduces convertibleCAR-T cells, a modular CAR system that can be controlled by bispecific adaptors and payloads, showing efficacy against tumors in mice.
bioRxiv · Nov 14, 2019Cancer Biology