Author

K. T. Roybal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. B. Abarientos· 1 shared A. Celli· 1 shared A. Hyrenius-Wittsten· 1 shared A. P. Wiita· 1 shared A. Pahl· 1 shared A. W. Li· 1 shared B. Liu· 1 shared C. A. Castellanos· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperCancer Biology

A. B. Abarientos

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Visualizing and manipulating hyperstabilization of T cell microvilli contacts by engineered chimeric antigen receptors

C. Beppler, J. Eichorst, K. Marchuk, E. Cai, C. A. Castellanos, V. Sriram, K. T. Roybal, M. F. Krummel

This study uses advanced imaging to show that engineered CARs with high affinity hyperstabilize T cell microvilli contacts, impairing function, while reducing affinity restores normal dynamics and improves effector function.

bioRxiv · Aug 18, 2021Immunology

Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma

J. H. Choe, P. B. Watchmaker, M. S. Simic, R. D. Gilbert, A. W. Li, N. A. Krasnow, D. A. Carrera, W. Yu, K. M. Downey, A. Celli, J. Cho, J. D. Briones, R. Dannenfelser, L. Cardarelli, S. S. Sidhu, , W. A. Lim

This study develops multiantigen recognition circuits for CAR T cells to improve specificity, heterogeneity, and durability in glioblastoma treatment.

bioRxiv · Jan 7, 2021 · PreprintImmunology

Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits

A. Hyrenius-Wittsten, Y. Su, M. Park, J. M. Garcia, N. Perry, G. Montgomery, B. Liu, K. T. Roybal

This study identifies ALPPL2 as a tumor-specific antigen and demonstrates that synNotch CAR T cells targeting it improve tumor control by reducing T cell exhaustion.

bioRxiv · Jan 6, 2021 · PreprintImmunology

CRISPR-based screens uncover determinants of immunotherapy response in Multiple Myeloma

P. Ramkumar, A. B. Abarientos, R. Tian, M. Seyler, J. T. Leong, M. Chen, P. Choudhry, T. Hechler, N. Shah, S. W. Wong, T. G. Martin, J. L. Wolf, K. T. Roybal, A. Pahl, J. Taunton, , M. Kampmann

This study uses CRISPR screens to identify mechanisms increasing BCMA expression and enhancing anti-myeloma efficacy of BCMA-targeted therapies in multiple myeloma.

bioRxiv · Apr 14, 2020Cancer Biology

convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

K. Landgraf, S. R. Williams, D. Steiger, D. Gebhart, S. Lok, D. W. Martin, K. T. Roybal, K. C. Kim

This paper introduces convertibleCAR-T cells, a modular CAR system that can be controlled by bispecific adaptors and payloads, showing efficacy against tumors in mice.

bioRxiv · Nov 14, 2019Cancer Biology